Responses from Caterina Fake, Ben Blumenfeld, Andrew Warner, Julie Zhuo, and myself. Here’s mine:
I loathe email. Unfortunately it’s still the primary means of most business communication over 140 characters. I used to try and keep my inbox below 50 items as regularly as possible. Now I get to email when I can, even if that means a swelling inbox. It’s just not worth it to me anymore to devote significant chunks of my day to managing email.
In other words: I don’t manage my email.